Московский семинар по биоинформатике. Игорь Жулин «Молекулярная эволюция многокомпонентой системы передачи информации у прокариотов»
Ближайшие события
Четверг, 25 октября 2007 года, 18.00, Институт молекулярной биологии им. Энгельгардта, комната 309
219-е заседание Московского семинара по биоинформатике.
Игорь Жулин
(Объединенный институт вычислительных исследований, Университет Теннесси — Окриджская национальная лаборатория)
«Молекулярная эволюция многокомпонентой системы передачи информации у прокариотов»
Igor B. Zhulin
(Joint Institute for Computational Sciences,
University of Tennessee — Oak Ridge National Laboratory)
"Molecular Evolution of a Complex Signal Transduction System in Prokaryotes"
Molecular machinery that governs bacterial motility (chemotaxis) is one of the best studied signal transduction systems in Nature [1]. Sophisticated behavior of Earth’s smallest organisms fascinated naturalists of the last century and modern biochemists, who hoped that the properties of the underlying molecular navigation system would resemble those of higher organisms. However, the latest structural and functional studies revealed no such similarity in the molecular design. Using the wealth of information encoded in hundreds of bacterial genomes we reconstructed the evolutionary history of this system. Here we show that the chemotaxis system is the evolutionary youngest and most sophisticated signal transduction pathway in prokaryotes. It appeared in Bacteria after the separation of the three domains of Life and has been later irradiated into Archaea, but not into Eucarya. It developed from classical bacterial two-component regulatory systems that, in turn, originated from simple one-component systems comprised of a single protein with sensory and regulatory capabilities that were likely present in the Last Universal Common Ancestor [2]. Through a series of domain innovations the chemotaxis system differentiated into several functional classes that evolved to control not only motility, but also other cellular functions. Detailed evolutionary analysis of individual system components allowed us to reveal novel structural and functional insights that have not been identified by previous experimental studies [3].
1. Wadhams GH & Armitage JP (2004) Nat Rev Mol Cell Biol 5:1024-1037.
2. Ulrich LE, Koonin EV & Zhulin IB (2005) Trends Microbiol 13: 52-56.
3. Alexander RP & Zhulin IB (2007) Proc Natl Acad Sci USA 104: 2885-2890.
Рабочий язык семинара — русский.
Адрес:
Москва, ул. Вавилова, 32, Институт молекулярной биологии им. Энгельгардта (ИМБ РАН), комната 309.
Проезд: станция метро «Университет» или «Ленинский проспект», далее трамваями № 14 или № 39 до остановки «Ул. Ляпунова» или «Ул. Бардина».
Схема проезда:
