3D bioprinting of tumor microenvironment: Recent achievements
a National Medical Research Centre for Oncology
14 Line str., 63, Rostov-on-Don, 344037 Russia
*e-mail: timofeeva.sophia@gmail.com
Advances in cell and molecular biology have led to the development of personalized medicine, aimed at adapting diagnostic and treatment methods for each individual patient. One of these advances is considered to be 3D bioprinting. 3D bioprinting methods allow to recreate the tumor microenvironment (TME) of the patient, most accurately reflecting the key stages of cancer spread, such as invasion, intravasation and angiogenesis.
Different types of cells are used as bio-ink for 3D printing, depending on the tumor. Research in this area is mainly focused on several areas: optimization of bio-ink and constructs, the choice between applying of immortalized or primary cell lines for printing, and testing of anticancer agents in 2D and 3D models of various malignant tumors. Thus, the development of 3D TME models creates conditions for optimizing the in vitro tumor treatment strategy. The review describes the existing 3D TME models of various types of cancer and the prospects for their adoption in oncology.
